HGH
PH-FRAG-001
Specifications
Description
HGH (human growth hormone) is offered as a research line in two distinct forms: the lipolytic C-terminal Fragment 176-191 and full-length 191-amino-acid somatropin, dosed in international units (36 IU). The two forms isolate different aspects of growth-hormone biology — selective fat metabolism versus complete somatotropic receptor signaling.
Fragment 176-191
The C-terminal fragment retains the fat-metabolizing region of hGH without its growth-promoting or diabetogenic properties. It activates lipolysis in adipose tissue without affecting blood glucose or IGF-1 levels, and does not bind the hGH receptor or induce hyperglycemia (Heffernan et al., 2001). Structurally related to AOD-9604, it increases fat oxidation and beta(3)-adrenergic receptor expression without the broader effects of full-length growth hormone (Heffernan et al., 2001).
- Molecular weight: 1817.1 Da; 16-amino-acid sequence (Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe)
- Selective fat-metabolism and lipolysis studies
- Obesity research without GH side effects
- Adipocyte biology and body-composition models
Full-Length 191-AA (36 IU)
Full-length recombinant human growth hormone (somatropin) is the complete 191-amino-acid polypeptide, structurally identical to pituitary-derived hGH. It binds the growth-hormone receptor to trigger JAK2/STAT5 signaling and downstream hepatic IGF-1 production, driving the full somatotropic program of protein synthesis, lipolysis, and cell proliferation. Supplied at 36 IU (~12 mg) per vial.
- Molecular weight: ~22,124 Da (≈22.1 kDa); 191 amino acids
- Growth-hormone receptor / JAK2-STAT5 signaling studies
- IGF-1 axis and endocrine research
- Body-composition, metabolic, and tissue-repair models
Product Specifications
- Purity: ≥99% (HPLC verified)
- Fragment 176-191: 1817.1 Da · Full-length 191-AA: ~22,124 Da
- Form: Lyophilized powder
- Storage: -20°C
References
- Heffernan MA, et al. "Increase of fat oxidation and weight loss in obese mice caused by chronic treatment with human growth hormone or a modified C-terminal fragment." Int J Obes Relat Metab Disord. 2001. PMID: 11673763
- Heffernan MA, et al. "The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and beta(3)-AR knock-out mice." Endocrinology. 2001. PMID: 11713213
Documentation
Storage and Handling
- ❄️ Store lyophilized peptide at -20°C or below
- 🔒 Protect from light and moisture
- 🌡️ Allow vial to reach room temperature before opening
- 💧 Reconstitute with appropriate sterile solvent
- 📦 Aliquot to avoid repeated freeze-thaw cycles
Research Overview
HGH is a synthetic peptide compound used in laboratory research settings. Researchers studying metabolic regulation and energy homeostasis use this compound to investigate cellular signaling pathways, receptor binding affinities, and structure-activity relationships. Each batch is manufactured under controlled conditions and verified through HPLC and mass spectrometry analysis to ensure consistency across experimental replicates.
Documentation & Resources
- Certificate of Analysis for HGH — batch-specific purity and identity verification
- Research Blog — protocols, guides, and peptide research literature
- Research Use Policy — handling and compliance guidelines
Frequently Asked Questions
What purity is HGH?
Each lot of HGH is verified to ≥99% by HPLC and confirmed by mass spectrometry. Results are documented in a batch-specific Certificate of Analysis.
Does HGH include a Certificate of Analysis?
Yes. A batch-specific Certificate of Analysis for HGH documents its purity and identity and is available on our COA page.
How should HGH be stored?
HGH is supplied as a lyophilized powder. For short-term storage keep it refrigerated; for long-term storage keep it frozen, away from light and moisture.
How is HGH shipped?
Orders ship at a $15 flat rate, free on orders over $199, in discreet, insulated packaging. Domestic delivery typically takes 1–3 business days.
Can HGH be used on humans or animals?
No. HGH is supplied strictly for in-vitro laboratory research. It is not for human or veterinary use, consumption, or diagnostic or clinical applications.
