MGF
PH-MGF-001
Specifications
Description
MGF (Mechano Growth Factor) is a splice variant of IGF-1 produced locally in muscle tissue in response to mechanical stress. This autocrine growth factor initiates satellite cell activation and muscle hypertrophy.
Mechanism of Action
MGF is expressed in response to mechanical signals and muscle damage, activating quiescent satellite cells to begin the repair process. The MGF-E peptide significantly increases the proliferative life span and delays senescence of satellite cells, enhancing their fusion potential at different ages (Kandalla et al., 2011). MGF is a putative product of IGF-I gene expression involved in tissue repair and regeneration (Goldspink, 2010).
Research Applications
- Muscle repair and regeneration (Kandalla et al., 2011)
- Satellite cell activation (Goldspink, 2010)
- IGF-1 splice variant research
- Mechanical signaling pathways
- Sarcopenia and muscle aging
Product Specifications
- Purity: ≥99% (HPLC verified)
- Molecular Weight: ~2800 Da
- Form: Lyophilized powder
- Storage: -20°C
References
- Kandalla PK, et al. "Mechano Growth Factor E peptide (MGF-E), derived from an isoform of IGF-1, activates human muscle progenitor cells and induces an increase in their fusion potential at different ages." Mech Ageing Dev. 2011. PMID: 21354439
- Goldspink G. "Minireview: Mechano-growth factor: a putative product of IGF-I gene expression involved in tissue repair and regeneration." Endocrinology. 2010. PMID: 20130113
Documentation
Storage and Handling
- ❄️ Store lyophilized peptide at -20°C or below
- 🔒 Protect from light and moisture
- 🌡️ Allow vial to reach room temperature before opening
- 💧 Reconstitute with appropriate sterile solvent
- 📦 Aliquot to avoid repeated freeze-thaw cycles
Research Overview
MGF is a synthetic peptide compound used in laboratory research settings. Researchers studying growth hormone releasing hormone pathways use this compound to investigate cellular signaling pathways, receptor binding affinities, and structure-activity relationships. Each batch is manufactured under controlled conditions and verified through HPLC and mass spectrometry analysis to ensure consistency across experimental replicates.
Documentation & Resources
- Certificate of Analysis for MGF — batch-specific purity and identity verification
- Research Blog — protocols, guides, and peptide research literature
- Research Use Policy — handling and compliance guidelines
Frequently Asked Questions
What purity is MGF?
Each lot of MGF is verified to ≥99% by HPLC and confirmed by mass spectrometry. Results are documented in a batch-specific Certificate of Analysis.
Does MGF include a Certificate of Analysis?
Yes. A batch-specific Certificate of Analysis for MGF documents its purity and identity and is available on our COA page.
How should MGF be stored?
MGF is supplied as a lyophilized powder. For short-term storage keep it refrigerated; for long-term storage keep it frozen, away from light and moisture.
How is MGF shipped?
Orders ship at a $15 flat rate, free on orders over $199, in discreet, insulated packaging. Domestic delivery typically takes 1–3 business days.
Can MGF be used on humans or animals?
No. MGF is supplied strictly for in-vitro laboratory research. It is not for human or veterinary use, consumption, or diagnostic or clinical applications.
