MOTS-c
PH-MOTSC-001
Specifications
Description
MOTS-c is a groundbreaking 16-amino acid mitochondrial-derived peptide (sequence: MRWQEMGYIFYPRKLR) encoded within mitochondrial DNA. This signaling peptide acts as a critical messenger between mitochondria and nucleus, orchestrating adaptive responses to metabolic stress.
Mechanism of Action
MOTS-c regulates the folate-methionine cycle and activates AMP-activated protein kinase (AMPK), a central cellular energy sensor. Under metabolic challenge, MOTS-c translocates to the nucleus and interacts with the antioxidant response element (ARE), upregulating stress resistance genes. MOTS-c is an exercise-induced mitochondrial-encoded regulator that significantly enhances physical performance across different age groups and can regulate both nuclear genes and skeletal muscle metabolism (Reynolds et al., 2021). The peptide promotes metabolic homeostasis and reduces obesity and insulin resistance (Lee et al., 2015).
Research Applications
- Metabolic regulation and insulin sensitivity studies (Lee et al., 2015)
- Exercise mimetic research and energy metabolism (Reynolds et al., 2021)
- Obesity and metabolic syndrome models
- Longevity and healthspan extension research
- Muscle homeostasis and sarcopenia
Product Specifications
- Purity: 99.789% (HPLC verified)
- Molecular Weight: 2174.6 Da
- Sequence: MRWQEMGYIFYPRKLR
- Form: Lyophilized powder
- Storage: -20°C, protected from light
References
- Reynolds JC, et al. "MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis." Nat Commun. 2021. PMID: 33473109
- Lee C, et al. "The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance." Cell Metab. 2015. PMID: 25738459
Documentation
Storage and Handling
- ❄️ Store lyophilized peptide at -20°C or below
- 🔒 Protect from light and moisture
- 🌡️ Allow vial to reach room temperature before opening
- 💧 Reconstitute with appropriate sterile solvent
- 📦 Aliquot to avoid repeated freeze-thaw cycles
Research Overview
MOTS-c is a synthetic peptide compound used in laboratory research settings. Researchers studying longevity and cellular aging research use this compound to investigate cellular signaling pathways, receptor binding affinities, and structure-activity relationships. Each batch is manufactured under controlled conditions and verified through HPLC and mass spectrometry analysis to ensure consistency across experimental replicates.
Documentation & Resources
- Certificate of Analysis for MOTS-c — batch-specific purity and identity verification
- Research Blog — protocols, guides, and peptide research literature
- Research Use Policy — handling and compliance guidelines
Frequently Asked Questions
What purity is MOTS-c?
Each lot of MOTS-c is verified to 99.789% by HPLC and confirmed by mass spectrometry. Results are documented in a batch-specific Certificate of Analysis.
Does MOTS-c include a Certificate of Analysis?
Yes. A batch-specific Certificate of Analysis for MOTS-c documents its purity and identity and is available on our COA page.
How should MOTS-c be stored?
MOTS-c is supplied as a lyophilized powder. For short-term storage keep it refrigerated; for long-term storage keep it frozen, away from light and moisture.
How is MOTS-c shipped?
Orders ship at a $15 flat rate, free on orders over $199, in discreet, insulated packaging. Domestic delivery typically takes 1–3 business days.
Can MOTS-c be used on humans or animals?
No. MOTS-c is supplied strictly for in-vitro laboratory research. It is not for human or veterinary use, consumption, or diagnostic or clinical applications.
