Mod GRF 1-29
PH-MODGRF-001
Specifications
Description
Mod GRF 1-29 (Modified GRF, CJC-1295 no DAC) is a modified analog of the first 29 amino acids of growth hormone-releasing hormone with enhanced stability. This tetrasubstituted peptide resists enzymatic degradation.
Mechanism of Action
Mod GRF 1-29 features four amino acid substitutions (positions 2, 8, 15, and 27) that protect against DPP-IV cleavage while maintaining GHRH receptor binding. These modifications extend half-life while preserving pituitary GH-releasing activity (Jette et al., 2005). GHRH-(1-29) administered twice daily reverses the decreased GH and IGF-I levels in elderly men (Corpas et al., 1992).
Research Applications
- Stabilized GHRH analog research (Jette et al., 2005)
- Pulsatile GH release studies (Corpas et al., 1992)
- Combined GHRH/GHRP synergy
- GH axis modulation
- Peptide stability research
Product Specifications
- Purity: ≥99% (HPLC verified)
- Molecular Weight: 3367.9 Da
- Form: Lyophilized powder
- Storage: -20°C
References
- Jette L, et al. "Human growth hormone-releasing factor (hGRF)1-29-albumin bioconjugates activate the GRF receptor on the anterior pituitary in rats: identification of CJC-1295 as a long-lasting GRF analog." Endocrinology. 2005. PMID: 15817669
- Corpas E, et al. "Growth hormone (GH)-releasing hormone-(1-29) twice daily reverses the decreased GH and insulin-like growth factor-I levels in old men." J Clin Endocrinol Metab. 1992. PMID: 1379256
Documentation
Storage and Handling
- ❄️ Store lyophilized peptide at -20°C or below
- 🔒 Protect from light and moisture
- 🌡️ Allow vial to reach room temperature before opening
- 💧 Reconstitute with appropriate sterile solvent
- 📦 Aliquot to avoid repeated freeze-thaw cycles
Research Overview
Mod GRF 1-29 is a synthetic peptide compound used in laboratory research settings. Researchers studying growth hormone releasing hormone pathways use this compound to investigate cellular signaling pathways, receptor binding affinities, and structure-activity relationships. Each batch is manufactured under controlled conditions and verified through HPLC and mass spectrometry analysis to ensure consistency across experimental replicates.
Documentation & Resources
- Certificate of Analysis for Mod GRF 1-29 — batch-specific purity and identity verification
- Research Blog — protocols, guides, and peptide research literature
- Research Use Policy — handling and compliance guidelines
Frequently Asked Questions
What purity is Mod GRF 1-29?
Each lot of Mod GRF 1-29 is verified to ≥99% by HPLC and confirmed by mass spectrometry. Results are documented in a batch-specific Certificate of Analysis.
Does Mod GRF 1-29 include a Certificate of Analysis?
Yes. A batch-specific Certificate of Analysis for Mod GRF 1-29 documents its purity and identity and is available on our COA page.
How should Mod GRF 1-29 be stored?
Mod GRF 1-29 is supplied as a lyophilized powder. For short-term storage keep it refrigerated; for long-term storage keep it frozen, away from light and moisture.
How is Mod GRF 1-29 shipped?
Orders ship at a $15 flat rate, free on orders over $199, in discreet, insulated packaging. Domestic delivery typically takes 1–3 business days.
Can Mod GRF 1-29 be used on humans or animals?
No. Mod GRF 1-29 is supplied strictly for in-vitro laboratory research. It is not for human or veterinary use, consumption, or diagnostic or clinical applications.
